Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications
نویسندگان
چکیده
منابع مشابه
Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs
Exposure to the agricultural fungicide vinclozolin during gestation promotes a higher incidence of various diseases in the subsequent unexposed F3 and F4 generations. This phenomenon is termed epigenetic transgenerational inheritance and has been shown to in part involve alterations in DNA methylation, but the role of other epigenetic mechanisms remains unknown. The current study investigated t...
متن کاملErratum: Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs
[This corrects the article DOI: 10.1093/eep/dvw001.].
متن کاملSperm-Mediated Transgenerational Inheritance
Spermatozoa of virtually all species can spontaneously take up exogenous DNA or RNA molecules and internalize them into nuclei. In this article I review evidence for a key role of a reverse transcriptase (RT) activity, encoded by LINE-1 retrotransposons, in the fate of the internalized nucleic acid molecules and their implication in transgenerational inheritance. LINE-1-derived RT, present in s...
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INTRODUCTION It is widely recognized that all that fathers essentially contribute to the next generation is half of their genome, and mature sperm cells are transcriptionally and translationally inactive. However, an increasing number of reports have shown that RNAs were present in human sperm detected by using RT-PCR, differential display, in situ hybridization and microarrays [1]. One study s...
متن کاملEpigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers.
The endocrine disruptor vinclozolin has previously been shown to promote epigenetic transgenerational inheritance of adult onset disease in the rat. The current study was designed to investigate the transgenerational actions of vinclozolin on the mouse. Transient exposure of the F0 generation gestating female during gonadal sex determination promoted transgenerational adult onset disease in F3 ...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2016
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg.2016.106